Urea Cycle Disorders Treatment

 Ravicti 25ml

Ravicti 25ml oral liquid is indicated for use as a nitrogen-binding agent for chronic management of patients with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or supplementation alone. Ravicti must be used with dietary protein restriction and, in some cases, dietary supplements (e.g. essential amino acids, arginine, citrulline, protein-free calorie supplements).
Ravicti 25ml


Warnings

Ravicti 25ml can affect your nervous system. Call your doctor right away if you have: confusion, headaches, memory problems, hearing problems, vomiting, an altered sense of taste, numbness or tingling in your hands or feet, or if you feel unusually sleepy or light-headed.

Before taking Ravicti 25ml

You should not use Ravicti if you are allergic to glycerol phenylbutyrate.
To make sure Ravicti is safe for you, tell your doctor if you have ever had:
  • liver or kidney disease;
  • a pancreas disorder;
  • stomach or intestinal disorder,
  • a condition called NAGS (N-acetylglutamate synthase) deficiency; or
  • if you use other medicines.
It is not known whether glycerol phenylbutyrate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you become pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of glycerol phenylbutyrate on the baby.
You should not breastfeed while using Ravicti 25ml.

How should I take Ravicti

Take Ravicti exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Ravicti 25ml is usually taken 3 times per day. Take with food or infant formula. If you are breastfeeding a baby who is taking this medicine, give each dose right before nursing.

Measure Ravicti liquid carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Ravicti 25ml may be given through a nasogastric (NG) or gastric feeding tube as follows: Measure the correct dose in the oral syringe, attach it to the feeding tube and push the plunger down to empty the syringe into the tube.

Flush the tube with 10 milliliters (ml) of water and allow the tube to drain. Follow this with 10 ml more of water to wash the contents down.

If you switch from sodium phenylbutyrate to Ravicti 25ml, your dose will not be the same. Follow your doctor’s dosing instructions very carefully.

Glycerol phenylbutyrate doses are based on body surface area (height and weight). Your dose needs may change if you gain or lose weight or if you are still growing.

You may need to follow a special diet while using Ravicti liquid. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

A buildup of ammonia in the blood can quickly cause brain injury or death. You will need frequent blood tests. Every person with a urea cycle disorder should remain under the care of a doctor.

Your name may be listed on a Urea Cycle Disorder registry. This is to collect information about people with these disorders and to evaluate the effects of treatment.

Store Ravicti at room temperature away from moisture and heat.

Ravicti side effects

Get emergency medical help if you have signs of an allergic reaction to Ravicti: hives; cough, wheezing, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any signs of high blood levels of ammonia (hyperammonemia):
  • weakness, lack of energy;
  • thinking problems, changes in behavior, feeling irritable;
  • breathing problems;
  • feeding problems; or
  • seizure (convulsions).
Ravicti 25ml can affect your nervous system. Call your doctor at once if you have:
  • drowsiness, unusual tiredness;
  • memory problems;
  • a light-headed feeling, like you might pass out;
  • confusion, ongoing headache, vomiting;
  • numbness, tingling, or burning pain in your hands or feet;
  • altered sense of taste; or
  • hearing problems.
Common Ravicti side effects may include:
  • occasional headache;
  • nausea, vomiting, diarrhea;
  • loss of appetite, gas, stomach pain;
  • dizziness, tiredness;
  • rash; or
  • (in children younger than 2 years) fever, cold or flu symptoms, cough, small bumps on the skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Enquire from Ozisik Eczane

What other drugs will affect Ravicti

Sometimes it is not safe to use certain medications at the same time. Certain other drugs can affect your blood levels of ammonia, making Ravicti less effective or causing hyperammonemia.

Many drugs can interact with glycerol phenylbutyrate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using. Ravicti 25ml Interactions



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